Acute administration of rt-PA for acute stroke in Pakistani patients--what does the available evidence teach us?

Although there is not a lot published about the administration of acute thrombolysis for stroke in Pakistan , studies show that despite the widespread absence of acute ambulance services and education, stroke is recognized early and about a quarter of the patients in urban areas present within the time window and are eligible for rt-PA. Additionally, the published studies show that our symptomatic ICH rates are unacceptably high-the reasons for which are yet to be elucidated. Keeping this in mind, the Japanese trial is particularly important as the risk of haemorrhage reported in our population with the conventional 0.9mg/kg dose is unacceptably high.